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Genetic Linkage

Human Embryonic Stem Cells Finally Reach Clinical Trials: Maurie’s Story

This is what Maurie Hill sees with her left eye covered when observing the eye chart from a meter away (credit: Derek Bove)
On July 11, Wills Eye Institute ophthalmologist Carl Regillo delicately placed 100,000 cells beneath the retina of 52-year-old Maurie Hill’s left eye. She was rapidly losing her vision due to Stargardt disease, an inherited macular dystrophy similar to the much more common dry age-related macular degeneration (AMD).

Maurie’s disease was far along, the normally  Read More 
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Guest Blog: "I'm in the ACT Stem Cell Trial for Stargardt Disease!"

Maurie Hill, after receiving retinal cells derived from human embryonic stem cells at the Wills Eye Institute in Philadelphia on July 11.
I am thrilled to introduce Maurie Hill, who is having her Stargardt disease (a form of early-onset macular degeneration) treated with retinal cells derived from human embryonic stem cells. I was going to write about her experience (and I will), but she is a great writer, and she and the Ai Squared Blog are sharing her story here. Welcome Maurie! Read More 
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Human Stem Cells from Amniotic Fluid

Stem cells from amniotic fluid are like Russian nesting dolls -- they are derived from the cells that would become sperm or eggs in a fetus.
A new source of human stem cells reminds me of Russian nesting dolls: They come from amniotic fluid. When exposed to a seizure drug (valproic acid), they divide to give rise to cells that can specialize as nearly any cell type – they are “pluripotent,” like embryonic stem (ES) cells. But the new stem cells are most like precursor cells in a fetus that become sperm and eggs. And so the cells derived from an organ in a pregnant woman might otherwise, if paired with the opposite type of sex cell, have become her grandchildren! Read More 
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Stem Cell Ups and Downs

We expect too much of stem cells. The February 3 issue of Nature reveals both a setback and a stupendous achievement in the field.

An article in the news section takes induced pluripotent stem cells (iPS cells) down  Read More 
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