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Genetic Linkage

Cow Embryos Reveal New Type of Chromosome Chimera

Cow embryos (credit: Maaike Catteeuw, Ghent University)
I’ve often wondered what happens between the time an egg is fertilized and the time the ball of cells that it becomes nestles into the uterine lining. It’s a period that we know very little about, a black box of developmental biology, because observing or doing anything to even the earliest human embryos is frowned upon.

Every time I write the following paragraph in new editions of my textbooks, I try to picture what can go wrong during those first cell divisions.

“The birth of a healthy baby is against the odds. Of every 100 eggs exposed to sperm, 84 are fertilized. Of these 84, 69 implant in the uterus, 42 survive one week or longer, 37 survive 6 weeks or longer, and only 31 are born alive. Of the fertilized ova that do not survive, about half have chromosomal abnormalities that cause problems too severe for development to proceed.” Read More 
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Eliza Gets Her Gene Therapy!

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Keeping a little girl at home for 722 days may seem cruel, but for the O’Neill family, it was a demonstration of astonishing bravery and love.

Glenn and Cara O’Neill had isolated their daughter Eliza to protect her from viral infection – which could have disqualified her from receiving gene therapy for Sanfilippo syndrome type A (aka mucopolysaccharidosis Type IIIA or MPS IIIA). Last week, she became patient #1 in Abeona Therapeutics' phase 1/2 clinical trial. Read More 
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