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Genetic Linkage

A Natural History Study Isn’t Necessarily About Dinosaurs

Many scientists trace their childhood inspiration to the towering skeletons of dinosaurs that still reign over the regal lobbies of the American Museum of Natural History, myself included. But “natural history” has a different meaning in medical research, especially in evaluating new treatments for rare diseases. Searching PubMed under “natural history study” turns up a curious 75,000 or so entries, including rare diseases and museum taxidermy.

A medical natural history study looks at how a disease unfolds over time, in real patients, to provide a point of comparison and variability for evaluating new treatments. A neurologist, for example, might know how to handle an otherwise healthy child with ADHD; a youngster with ADHD as part of Sanfilippo syndrome presents a different clinical picture. A natural history study provides an idea of what to expect.

To continue reading go to DNA Science, my blog at Public Library of Science, where this post first appeared.
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