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Genetic Linkage

‘Lessons in Chemistry’: New Apple TV series based on best-selling book has opportunity to skewer sexism while challenging the ‘nerd stereotype’

I loved Lessons in Chemistry, the hit novel by Bonnie Garmus, and I'm thrilled that Apple TV+ picked it up "straight-to-series" more than a year before it was published in March 2022. Executive Producer Brie Larson, of "Room" and "Captain Marvel" fame, stars as chemist-turned-TV-cook Elizabeth Zott.

The book is hilarious, fast-paced, and expertly plotted. But while the feminist message is obvious, the subtext simmers with a disturbing "othering" of scientists. Let's see what happens with the TV version, which debuts in 2023.

 

Book synopsis


In 1956 Elizabeth Zott works at the Hastings Research Institute in Commons, California, "EZ" emblazoned on her lab coat. She has a master's in chemistry, which in science generally means failing to pass qualifying exams — sometimes it's even called a "terminal masters," like a cancer. 

 

When she hunts for spare beakers in the lab of star chemist Calvin Evans, he assumes she's a secretary. Two weeks later, they bump into each other at an operetta and Calvin, sick from something he ate and after his date bolts, promptly barfs on her. 

 

The two share interests, traumatic upbringings, and a physical attraction that neither at first wants to acknowledge. But they bond (more a covalent sharing than an ionic exchange). She tends to get on her soapbox, lamenting the system that keeps women out of science. 

 

"'You're saying,' he said slowly, 'that more women actually want to be in science,'" Calvin probes incredulously. 

 

To continue reading, go to Genetic Literacy Project, where this post first appeared. 

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My Five-Year Breast Cancerversary

Five years ago today, I learned that I had breast cancer.

 

I didn't find out in the usual way, an alarmingly ambiguous phone call and then a sit-down with my doctor. The radiologist knew I saw patients in the office for genetic counseling, so while I was getting dressed after my annual mammogram, she beckoned me to her nearby office.

"Take a look at the two screens, Ricki. The left one is last year's image."

 

It didn't take training in radiology to see that something had happened since last year's mammogram. On the right screen, a small mass blocked a narrow passageway, a milk duct.

 

When the radiologist enlarged the image, the clump of cells was not only blocking the duct, but pushing against one wall. I realized instantly that if I had skipped my mammogram that year, the next year's scan would have shown invasive cancer.

 

 

To continue reading, go to DNA Science, where this post first appeared.

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Halloween Evokes Thoughts on Organoids

When the jello brains and gummy organs of Halloween come out, my thoughts turn to organoids. These are tiny organs, or parts of them, grown in lab dishes or transplanted into rodents, so we can watch a disease begin and maybe even test a candidate drug. Organoid technology isn't a headline hog like CRISPR, but it's intriguing, and certainly easier to envision.

 

Organoids that appear from dividing stem cells offer a landscape of early development – the process of organogenesis. A heart, liver, or kidney takes form from dividing, folding, and interacting cells, a little like watching a photographic image emerge and sharpen in a pan of developer, for those who remember that technology.

 

To continue reading. go to DNA Science, where this post first appeared.

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Men Can't Do Zumba. Is It In Their Genes?

Zumba saved me during the pandemic. Prior to COVID, I took 3 or 4 of the ATP-burning classes a week (for the uninitiated, ATP stands for adenosine triphosphate, the molecule that cells split to release energy). But in March 2020, when the world shut down, my beloved dance classes suddenly ceased. I remember my last class. Only ten people attended, because so many were already too scared to venture out. 

 

As lockdown continued, I found thousands of dance videos online, favoring a blond woman instructor from Germany and groups of teens from the Philippines and South Korea. It felt worldly while being trapped. My local Zumba instructors quickly reinvented themselves for zooming. Then when the world started to open up again, I returned to classes, masked until that, too, was dropped.

 

The one thing that stood out, especially during COVID, was how few men participated. Part of the reason may be a reaction to what some may have felt was a 'girly' exercise. But is something else going on here?

 

To continue reading, go to Genetic Literacy Project, where this post first appeared.

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The Age of the Pangenome Dawns

"Pan" has several meanings.

 

As a noun, it refers to "a round metal container that often has a long handle and a lid."

 

As a verb, it means criticism, like panning a film.

 

Peter Pan refers to an adult who doesn't want to behave like one, from Sir James Barrie's play about the boy who didn't want to grow up

 

As a prefix, "pan," from the Greek, means "all, every, whole, and all-inclusive."

 

Sigmund Freud reportedly used the term pan-sexualism in 1914, to mean "sex as a motivator of all things."

 

In genetics, the human pangenome is a complete reference of human genome diversity. It is envisioned as a new type of map that represents all of the ways that the sequence of 3,054,832 billion DNA base pairs – the building blocks of a genome – vary, plus or minus a few from short repeated sequences. The depiction is so densely packed that it resembles a map of the New York City subway system.

 

The Human Pangenome Reference Consortium is spearheading creation of a "genome reference representation that can capture all human genome variation and support research on the full diversity of populations."

 

 

To continue reading, go to DNA Science, where this post first appeared.

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Nobel Prize to Paleogenetics Rockstar Svante Pääbo Evokes Memories of Being Drawn to Science

One of my favorite places as a child was the American Museum of Natural History. While most kids would rush to the towering dinosaur skeletons, I'd stand, transfixed, at a small glass-enclosed display of skulls and try to envision what their owners had looked like – australopithecines, Neanderthals, a few others. I remember that part of the museum as The Hall of Man; it's now the Hall of Human Origins.

 

Discovering My First Fossil

 

I loved the museum, but yearned to discover things myself. That happened when I was in the fourth grade, and my parents took my sister and me to the Baseball Hall of Fame in Cooperstown, NY. We couldn't have cared less about baseball. But behind the motel, we waded in a stream, where the angle of the sun on the wet rocks revealed striking patterns of stripes. I picked one up, and realized that it wasn't an ordinary rock.

 

It was a fossil. Edith and I spent the weekend collecting.

 

To continue reading, go to DNA Science, where this post first appeared.

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Two Newly-Approved Gene Therapies Cost Millions

The FDA recently approved two gene therapies with hefty price tags, the first for an inherited anemia and the second for a degenerative brain condition. The two new treatments, from bluebirdbio, double the number of gene therapies on the market.

 

Most biotechnologies evolve over three decades or so, but the idea of gene therapy has been around since the late 1950s, blooming soon after Watson and Crick solved the structure of DNA. When my book The Forever Fix: Gene Therapy and the Boy Who Saved It was published a decade ago, it would still be 5 years before the first approval. That treatment, the subject of my book, enabled the blind to see, sometimes in just days.

 

Why has the pace of gene therapy been so slow? Cost is one barrier. Other concerns are the degree to which a gene therapy actually helps, how long the effect lasts, and what proportion of patients respond.

 

A Short List

 

FDA's gene therapy roster is here, but a caveat is necessary.

 

 

To continue reading, go to DNA Science, where this post first appeared.

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Thoughts on a Return of Polio

When a case of polio showed up in Rockland county, just north of New York City, in July 2022, and then polioviruses with the same genetic sequence as from the paralyzed man were found in three samples of wastewater collected from near his home, public health officials were alarmed. The man, from an Orthodox Jewish community with low vaccination rates in general, had not been immunized against polio.

 

Definitions from the World Health Organization kicked in.

 

The viral RNA sequence from the patient was close to that of oral polio vaccine, which is "live" (weakened, aka attenuated). He was infected with vaccine-derived polioviruses (VDPV). Then finding the telltale RNA sequence in wastewater elevated the situation to circulating vaccine-derived polioviruses (cVDPV). The US now joins 30 other nations experiencing a return of this infectious disease that was once thought to be nearly gone.

 

To continue reading, go to DNA Science, where this post first appeared. 

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Mellow Yellow: A Biotech Way to Make Saffron

Biotechnology mass-produces valuable molecules from nature, from drugs to textiles to a jellyfish protein that lights up most anything a glowing green. Now add saffron to the list.

 

To cooks, saffron is a bright yellow spice derived from Crocus sativus flowers, aka "saffron crocus." The dried red threads at the blooms' centers are used to season and color foods. Popular for thousands of years, saffron comes today mostly from Iran. It's used to infuse meats, grains, salads, and even to color marshmallows molded into baby chick shapes for Easter.

 

Saffron has medicinal potential. The main pigment crocin may be useful as a neuroprotectant, an antidepressant, a sedative, and an antioxidant.

 

Inspiring a Song

To those of us of a certain age, the word "saffron" conjures up "mellow yellow," a 1966 song by Donovan:

 

I'm just mad about saffron
A-saffron's mad about me …
They call me mellow yellow …

 

To continue reading, go to DNA Science, where this post first appeared.

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Can Curcumin, Black Pepper, and Ginger Treat Retinitis Pigmentosa? Steve Fialkoff’s Excellent Experiment

Steve Fialkoff and I weren't friends at James Madison High School in Brooklyn, NY. We were in the class of 1972; earlier alums include Chuck Schumer, Bernie Sanders, and Carole King. The near-thousand of us self-sorted into three cliques, based on neighborhood. Steve was from Mill Basin, me Kings Highway.

 

While super-popular Steve was everywhere with his massive blond 'fro, capturing our experiences with his camera and leading the class in drama productions, I was on the fast track to nerddom. I spent my time in the chem lab with the groovy new teacher in charge, a 24-year-old who showed my bestie Wendy and me how to make bongs and water pipes. But Steve now says he was a closet nerd, a "frizzy-haired, freckle-faced, big-nosed, crooked-smile, toothy guy."

 

It wasn't surprising that Steve became a film editor and now a playwright. What was surprising was learning at age 25 that he had retinitis pigmentosa, after he tripped over a seat in a darkened theater and had a few other stumbles.

 

To continue reading, go to DNA Science, where this post first appeared.

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