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Genetic Linkage

OrganEx Revives Pigs an Hour After Death, Holding Promise for Transplants

Transplant medicine could take a giant leap forward if donor organs could soak up oxygen for longer and decay delayed. A technology called OrganEx, described in Nature from a team at Yale, promises to do just that. The researchers stopped the hearts of pigs and an hour later used OrganEx, then cataloged the return of bodily functions. The new approach far exceeded the ability of existing technology to prolong organ viability.

 

Popular Pigs

Pigs have long been a popular animal model of human disease because they are about our size and their hearts and blood vessels are quite similar. They have also had fictional roles in medicine.

 

 

To continue reading go to DNA Science, where this post first appeared. 

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Did a Virus Type Used in Gene Therapy Cause the Recent Wave of Hepatitis in Kids?

The last thing the field of gene therapy needs is another setback. Two studies, not yet peer-reviewed, point to adeno-associated virus (AAV) as a suspect behind the unusual hepatitis that emerged in children in April 2022.

AAV has been critical to the development of gene therapy, as carriers of human genes in the single strand of DNA that is the viral genome.

 

AAV has been considered relatively harmless, as viruses go. It was discovered in 1965 as a tiny tag-along that will only replicate in human cells if adenovirus is also there at some point – hence the "adeno-associated." AAV infection can also accompany certain herpes infections. Several subtypes of AAV have since been identified; AAV2 and AAV9 are gene therapy favorites. And they're common. Eighty percent of us harbor AAV2.

 

To continue reading, go to DNA Science, where this post first appeared. 

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From Doodle Dogs to COVID: On the Meaning of Wild Type

Zeke, shown here retrieving a stick from the surf at Lambert's Cove, Martha's Vineyard, is an aussiedoodle – a cross between an Australian shepherd and a poodle. I did an informal survey there over the course of a week, and estimated that approximately 70 percent of the dogs on the beach harbored poodle genes.

 

Diverse doodles share the trademark tight curly fur, but vary in size, color, head shape, and behavioral and other traits. Several websites list 50+ variations on the poodle hybrid theme, including the bassetoodle, bernedoodle, chipoo, doxiepoo, Irish doodle, poochon, rottle, and shihpoo.

 

Why poodles? The breed evokes such effusive descriptions as "confident yet affectionate, but also active and deceivingly athletic. What's not to like about the dignified and elegant Poodle?" The mixes are deemed highly intelligent, although I can't imagine any of my cats chasing a stick, let alone retrieving it.

 

Perhaps I was witnessing a biased sampling, and the doodles simply have a combination of gene variants that somehow makes them love running in the sand. I watched, transfixed, as a goldendoodle followed a seabird far out into the surf, upsetting the human observers and revealing a superior avian intelligence.

 

To continue reading, go to DNA Science, where this post first appeared.

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Y Chromosome Loss Linked to Hiked Heart Disease Risk: The Human Y Isn’t Useless After All

I've never been fond of the human Y chromosome. Yes, the all-important SRY gene sets the early embryo on a path towards maleness, but the rest? Mostly DNA borrowed from a long-ago X, peppered with eight long palindromes.

 

"The Y is a pathetic little chromosome with lots of junk. It is gene-poor, prone to deletion, and useless. You can lack a Y and not be dead, just female," Jennifer Marshall Graves told me years ago when I defiled the Y in The Scientist. She's professor emeritus of Australian National University, an evolutionary geneticist who works on kangaroos, platypus, Tasmanian devils, and various dragon lizards.

 

But men missing the Y in some of their white blood cells face heightened health risks. That was a mere association a few years ago, but now appears to be causal, according to results of an investigation in Science from researchers at Uppsala University. The research combines clues from mouse studies and epidemiological data from the UK Biobank.

 

To continue reading go to DNA Science, where this post first appeared.

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Repealing Roe: A View from a Long-time Biology Textbook Author

The Supreme Court justices who dismantled Roe v Wade in Dobbs v Jackson Woman's Health Organization should have taken a refresher course in Bio 101. Their decision is devoid of anything even hinting at modern medical science.

 

The American College of Obstetrics and Gynecology today released a joint statement from more than 75 health care organizations "in opposition to legislative interference" with women's health care. They conclude:

 

"Abortion care is safe and essential reproductive health care. Keeping the patient–clinician relationship safe and private is essential not only to quality individualized care but also to the fabric of our communities and the integrity of our health care infrastructure. As leading medical and health care organizations dedicated to patient care and public health, we condemn this and all interference in the patient–clinician relationship."

 

I couldn't agree more.

 

To continue reading, go to DNA Science, where this post first appeared.

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Jurassic World: Dominion Bashes Biotech

If a new Planet of the Apes or Jurassic Park film comes out, I'm going to go see it. The latest, Jurassic World:Dominion, didn't disappoint.

 

A Plague of Locusts

 

The science is mostly accurate, the bioethics message obvious, and the plot adheres to Isaac Asimov's "change one thing" rule for science fiction. In the world of Jurassic Park, that lone variable is time. We just have to accept that a "titanosaur" like Argentinosaurus somehow grew and developed from a lab-nurtured baby to a 130-foot-tall and 110-ton adult in a few years.

 

The official summary from IMDb for the new film is vague and continues the impossibly-rapid-growth theme:

Four years after the destruction of Isla Nublar, dinosaurs now live–and hunt–alongside humans all over the world. This fragile balance will reshape the future and determine, once and for all, whether human beings are to remain the apex predators on a planet they now share with history's most fearsome creatures in a new Era.

 

Four years? Animals radiating around the world? Even rats or rabbits couldn't do that. And the film is actually more about insects.

 

To continue reading, go to DNA Science, where this post first appeared.

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Our Father on Netflix depicts the dark side of ‘secret serial sperm donation’. My story is more positive.

"Our Father" is difficult to watch, especially if you've suddenly discovered as an adult that you have a never-known family of half-siblings, cousins, nieces, and nephews thanks to a long-ago sperm donation. One review dubs the series "Netflix's most gruesome real-life documentary yet." 

 

It tells the tale of Indianapolis fertility physician Donald Cline, who used his sperm to inseminate at least 96 women (and counting) between 1979-1986. After years of being in the dark, the offspring have found each other thanks to diligent sleuthing by some of the half-siblings and DNA testing. 

 

"The majority of us live in a 25-mile radius, some within minutes of Cline. I walk around and I could be related to anyone. I've probably met half sibs and we don't even know it," said a son named Guy.

 

To continue reading, go to Genetic Literacy Project, where this post first appeared.

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I write about the history of genetics. Buffalo racially-motivated massacre refocuses attention on the dark side of the 100-year old eugenics movement

Whenever I work on a new edition of my human genetics textbook and reach the section on eugenics, which flourished in the United States in the 20th century well into the 1930s, I'm relieved that it's history. But in the summer of 2017, as I wrapped up the 12th edition, the eugenics coverage took on a frightening new reality with the attack in Charlottesville, where white supremacists bellowed "Jews will not replace us!" A president noted at the time, "there are very fine people on both sides."

 

It's now 2022. I've just finished revamping the section in my textbook on eugenics for the 14th edition. And once again, eugenics is in the headlines, with the attack on Black shoppers at a supermarket in Buffalo, New York. 

 

As another president once said, "here we go again."

 

To continue reading, go to Genetic Literacy Project, where this post first appeared.

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Time Travel, Sea of Tranquility, and the History of Genetics

Tales of time travel have intrigued me since The Time Machine film scared the crap out of me at my cousin Ron's ninth birthday party. Now The Time Traveler's Wife, a novel from 2003 and film from 2009, has resurfaced in series form on HBO.

 

Emily St. John Mandel's new novel Sea of Tranquility also follows a time traveler, across five centuries. The tale begins in 1912 in Canada and ends, if you look at time as linear rather than looped, in a dark, domed moon colony. The author wrote Station Eleven, so I was thrilled that she has a new book. Although it's fiction, events during the middle time period unfold during a pandemic. It is an eerily familiar backdrop.

 

The Star Trek Futuristic Precedent

 

The #1 rule of time travel: you can't go back and change anything. A poignant demonstration of this edict is "The City on the Edge of Forever," considered by some to be the best installment of any Star Trek series ever. It was the penultimate episode of the first season, debuting on NBC on April 6, 1967 and written by Harlan Ellison.

 

To continue reading, go to DNA Science, where this post first appeared. 

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Can Chewing Gum Protect Against COVID?

When I was growing up in the 1960s, chewing gum was a big deal.

 

TV ads showcased the doublemint twins and their stick gum, and the small squares of chiclets. Kids preferred tiny bricks of pink Bazooka with the folded-up shiny papers bearing dumb comics. Girls collected rectangular

Juicy Fruit wrappers, folding them thrice in two dimensions and linking them into loooong chains that we'd save for our future first boyfriends.

 

We had tea-flavored teaberry gum, and a yummy licorice one with a name that is probably no longer politically correct.

 

Trident gum offered a sugar-free option, while Dentyne gave the illusion of health. New York City pharmacist Franklin V. Canning invented the gum in 1899, formulated to "sweeten the breath, to keep teeth white," according to the wrapper. Dentyne cleverly combines "dental" and "hygiene."

 

And an ancient song was entitled, "Does your chewing gum lose its flavor on the bedpost overnight?"

 

To continue reading, go to DNA Science, where this post first appeared.

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