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Genetic Linkage

Looking Into a COVID Lung Using Spatial Transcriptomics

As the early weeks of the pandemic unfolded and health care workers struggled to save so many lives, researchers began tracking the path of destruction of SARS-CoV-2, focusing at first on the tango between cells of the lung and of the immune system.


Just as mRNA vaccine technology was years in the making, so was a powerful way to illuminate cellular pathology: single-cell transcriptomics using single-cell RNA-Seq, aka simply RNA-Seq. It detects the abundance of all unique messenger RNA (mRNA) molecules in a cell, collectively called the transcriptome. RNA-Seq reveals the suite of proteins a cell produces in response to a stimulus – such as an influx of viruses. The technology is more than a decade old.


But cataloging the abundance of mRNAs in a lung cell, or in any cell, isn't meaningful without the context of the organ of which it is a part. It's a little like counting the number of times the words "the," "a," and "there" appear in a novel and trying to deduce the narrative.


To continue reading, go to DNA Science, where this post first appeared.

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