icon caret-left icon caret-right instagram pinterest linkedin facebook twitter goodreads question-circle facebook circle twitter circle linkedin circle instagram circle goodreads circle pinterest circle

Genetic Linkage

Mutations in Three Genes Protect Against Alzheimer’s

The plaques and tangles of an Alzheimer's brain. 

Clues to combatting a devastating disease can come from identifying people who have gene variants – mutations – that protect them, by slowing the illness or lowering the risk that it develops in the first place. Understanding how they do this may inspire treatment strategies for the wider patient population.


Rare variants of three well-studied genes appear to delay inherited forms of Alzheimer's disease – by decades.


Gene #1: The Famous Case of Aliria from the Colombian Family

In 2019. researchers reported on a patient, Aliria Rosa Piedrahita de Villegas, who seemed to have fended off early-onset familial Alzheimer's thanks to a variant of a second, apparently protective gene. The report appeared in Nature Medicine.

Be the first to comment

Genes That Protect Against Dementia (Maybe)

Elders with excellent cognition and memory help their grandchildren survive.
"Survival of the fittest" is one of the most misunderstood terms in biology. Evoking images of physical prowess, it actually refers to an individual inheriting traits that increase the chances of having fertile offspring, such as brilliant plumage or a high sperm count. But according to an intriguing study published recently in  Read More 
Be the first to comment