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Glenn Nichols, surrounded by his hospice team. The author is in yellow.

Genetic Linkage

Prenatal Genetic Testing of Pap Smears

November 2, 2016

Tags: prenatal diagnosis

Anthony Weiner and Woody Allen have the same favorite organ; mine is the placenta.

The amazing placenta literally links generations, and if findings reported in the new Science Translational Medicine are validated, prenatal genetic screening and testing may become possible using Pap smears – as early as 5 weeks after conception. (more…)

Male DNA in Female Brains Revisited

October 25, 2012

Tags: microchimerism, prenatal diagnosis, genetic testing, systemic sclerosis, cell-free fetal DNA, non-invasive prenatal testing

Fetal cells remain in moms -- that isn't news. But the discovery of fetal DNA in women's brains is. (credit: Jay Shendure lab)
“Some women actually have men on the brain” beckoned the headline from the LA Times on September 27, echoing an article in PLoS One describing the discovery of male fetal DNA in the brains of pregnant women. It was “an astonishing finding,” according to the newspaper, necessitating “a new paradigm of the biological self” according to lead author J. Lee Nelson of the Fred Hutchinson Cancer Research Center and the University of Washington.

I suspect Dr. Nelson was quoted out of context, for the idea of two genetically distinct populations of cells, or their DNA, residing in one individual isn’t new. It’s called microchimerism. (more…)

instruction
Project to engage students in helping families with rare genetic diseases
Book Club Reader's Guide
Many challenging questions to stimulate thought and discussion.
Instructor's Guide
38 discussion questions to get students thinking and talking about gene therapy, including the science, ethical issues, and the drug approval process.
Narrative science
The Forever Fix is the uplifting true story of 8-year-old Corey Haas, who was cured of hereditary blindness just 4 days after gene therapy.
College Textbooks
A spectacularly-illustrated, clearly written human anatomy and physiology textbook, used in pre-health profession programs throughout the U.S.
A highly engaging, clearly written, beautifully illustrated introduction to the science of human genetics for the non-scientist. Now in its 11th edition, 12th to be published in September 2018.
Nonfiction
An ideal starting point for anyone who wants to know more about genes, DNA, genomes, and the genetic ties that bind us all.

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