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Glenn Nichols, surrounded by his hospice team. The author is in yellow.

Genetic Linkage

Mice With Human Liverlets Test New Drugs

November 17, 2012

Tags: drug-drug interactions, drug development, hepatitis C, mouse models

Mice with human livers are better models for spotting drug-drug interactions than are mice with only their own livers.
“Scientists at Stanford have produced mice with human brains, pigs with human blood flowing through their veins, and a human born to mice parents and mice with human heads.”

So wrote a student summarizing the “Genetically Modified Organisms” chapter of my human genetics textbook a few years ago. Two of the four comments are true, sort of.
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instruction
Project to engage students in helping families with rare genetic diseases
Book Club Reader's Guide
Many challenging questions to stimulate thought and discussion.
Instructor's Guide
38 discussion questions to get students thinking and talking about gene therapy, including the science, ethical issues, and the drug approval process.
Narrative science
The Forever Fix is the uplifting true story of 8-year-old Corey Haas, who was cured of hereditary blindness just 4 days after gene therapy.
College Textbooks
A spectacularly-illustrated, clearly written human anatomy and physiology textbook, used in pre-health profession programs throughout the U.S.
A highly engaging, clearly written, beautifully illustrated introduction to the science of human genetics for the non-scientist. Now in its 10th edition.
Nonfiction
An ideal starting point for anyone who wants to know more about genes, DNA, genomes, and the genetic ties that bind us all.

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