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Glenn Nichols, surrounded by his hospice team. The author is in yellow.

Genetic Linkage

A Necessary Retelling of the Smallpox Vaccine Story

January 17, 2017

Tags: vaccine, smallpox, Edward Jenner, Donald Trump, RFK Jr, autism, anti-vaxxer

People once feared that small cows would emerge from the arms of vaccinated people. Ignorance about vaccines persists.
A curious confluence of events unfolded January 10. Just hours before President Obama uttered the powerful “science and reason matter” in his farewell address, Robert F. Kennedy Jr. announced that the incoming president had tapped him to head a committee on vaccine safety.

RFK Jr. is not a pediatric immunologist nor an epidemiologist, but a vocal "vaccine skeptic". Although the PEOTUS dialed back on the purported appointment shortly after social media erupted, a tweet from March 28, 2014 clarifies the new president’s analysis of the history and science of vaccines:

Healthy young child goes to doctor, gets pumped with massive shot of many vaccines, doesn’t feel good and changes – AUTISM. Many such cases! (more…)

Autism Gene Discovery Recalls Alzheimer’s and BRCA1 Stories

March 26, 2015

Tags: autism, Alzheimer's disease, BRCA1 breast cancer

Discovery of a new gene behind autism cleverly combines genetic techniques new and classic.

Autism has been difficult to characterize genetically. It is probably a common endpoint for many genotypes, and is a multifactorial (“complex”) trait. That is, hundreds of genes contribute risk to different degrees, as do environmental factors. Research reports implicate either dozens of genes in genomewide sweeps, or focus on a few genes that encode proteins that act at synapses, such as the < href="https://www.autismspeaks.org/science/grants/neuroligins-and-neurexins-autism-candidate-genes-study-their-association-synaptic-con">neuroligins and neurexins. (more…)

Prenatal Genetic Testing: When is it "Toxic Knowledge"?

October 18, 2012

Tags: prenatal genetic testing, chromosomal microarray, copy number variant, autism, developmental delay

Can prenatal genetic test results destroy the joy of pregnancy? (Credit: Jane Ades, NHGRI)
When I was a fetus, I was left alone. My amniotic fluid and chorionic villi were untouched, and I arrived apparently normal, except for a mark on the part of my anatomy where a bullet “directly bit” Forrest Gump.

Perhaps that’s too much information. (more…)

instruction
Project to engage students in helping families with rare genetic diseases
Book Club Reader's Guide
Many challenging questions to stimulate thought and discussion.
Instructor's Guide
38 discussion questions to get students thinking and talking about gene therapy, including the science, ethical issues, and the drug approval process.
Narrative science
The Forever Fix is the uplifting true story of 8-year-old Corey Haas, who was cured of hereditary blindness just 4 days after gene therapy.
College Textbooks
A spectacularly-illustrated, clearly written human anatomy and physiology textbook, used in pre-health profession programs throughout the U.S.
A highly engaging, clearly written, beautifully illustrated introduction to the science of human genetics for the non-scientist. Now in its 10th edition.
Nonfiction
An ideal starting point for anyone who wants to know more about genes, DNA, genomes, and the genetic ties that bind us all.

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