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Glenn Nichols, surrounded by his hospice team. The author is in yellow.

Genetic Linkage

Blinded By Stem Cells

March 19, 2017

Tags: stem cells, age-related macular degeneration, stem cell tourism

Age-related macular degeneration slowly destroys central vision.
The small wavy shimmers and fuzzy areas in the 78-year-old’s eyes had grown slowly, leading to a diagnosis of age-related macular degeneration (AMD), which affects more than 10 million Americans. She had the more common “dry” form. Despite 2 years of injections of one of the latest drugs (a vascular endothelial growth factor [VEGF] blocker), her sight was worsening. How much longer would she be able to drive, with a growing blob obscuring the center of her visual world?

Her family went online to research alternative approaches. (more…)

Retinal Stem Cells and Eye of Newt

January 16, 2013

Tags: stem cells, RPE, age-related macular degeneration, iPS cells, Neural Stem Cell Institute, Foundation Fighting Blindness

Human RPE cells in culture look like cobblestones; 3% of them behave like stem cells, in dishes. Can they treat eye diseases from within? (Tim Blenkinsop)
More than a decade before Sally Temple, PhD, and her husband Jeffrey Stern, MD, PhD, discovered stem cells in human eyes, they suspected the cells would be there. They knew it from the salamanders.

A SPECIAL FONDNESS FOR AMPHIBIANS
When William Shakespeare included “eye of newt” ingredients of the Three Witches’ brew in Macbeth, he probably knew what he was doing. Dr. Temple, who grew up in northern England, said it’s long been common knowledge there that newts can regrow their parts. In the late 1800s, biologists began to study regeneration in salamanders.

By the 1950s, embryologists had discovered that certain amphibian eyes regenerate thanks to a single layer of cells, called the retinal pigment epithelium (RPE), which hugs the photoreceptors (the rods and cones). (more…)

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Project to engage students in helping families with rare genetic diseases
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Many challenging questions to stimulate thought and discussion.
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38 discussion questions to get students thinking and talking about gene therapy, including the science, ethical issues, and the drug approval process.
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The Forever Fix is the uplifting true story of 8-year-old Corey Haas, who was cured of hereditary blindness just 4 days after gene therapy.
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A spectacularly-illustrated, clearly written human anatomy and physiology textbook, used in pre-health profession programs throughout the U.S.
A highly engaging, clearly written, beautifully illustrated introduction to the science of human genetics for the non-scientist. Now in its 11th edition, 12th to be published in September 2018.
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An ideal starting point for anyone who wants to know more about genes, DNA, genomes, and the genetic ties that bind us all.

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