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Glenn Nichols, surrounded by his hospice team. The author is in yellow.

Genetic Linkage

Retinal Stem Cells and Eye of Newt

January 16, 2013

Tags: stem cells, RPE, age-related macular degeneration, iPS cells, Neural Stem Cell Institute, Foundation Fighting Blindness

Human RPE cells in culture look like cobblestones; 3% of them behave like stem cells, in dishes. Can they treat eye diseases from within? (Tim Blenkinsop)
More than a decade before Sally Temple, PhD, and her husband Jeffrey Stern, MD, PhD, discovered stem cells in human eyes, they suspected the cells would be there. They knew it from the salamanders.

A SPECIAL FONDNESS FOR AMPHIBIANS
When William Shakespeare included “eye of newt” ingredients of the Three Witches’ brew in Macbeth, he probably knew what he was doing. Dr. Temple, who grew up in northern England, said it’s long been common knowledge there that newts can regrow their parts. In the late 1800s, biologists began to study regeneration in salamanders.

By the 1950s, embryologists had discovered that certain amphibian eyes regenerate thanks to a single layer of cells, called the retinal pigment epithelium (RPE), which hugs the photoreceptors (the rods and cones). (more…)

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