12th edition of my human genetics textbook


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Glenn Nichols, surrounded by his hospice team. The author is in yellow.

Genetic Linkage

How Genetic Testing Guided My Breast Cancer Journey Ė To Eschewing Beef

January 15, 2018

Tags: breast cancer, BRCA

Two months ago, I joined a club nobody wants to be a member of Ė the 1 in 8 women who develop breast cancer at some point in their lifetimes. It turned up on a routine mammogram.

Iím happy that itís okay these days to talk about breast cancer Ė when my mom first had it in 1988, that wasnít true. I havenít thought much yet about marching and holding a sign next October for Breast Cancer Awareness month. I donít have the strength to hold a sign right now, but Iím trying to help by explaining things on the Facebook groups of ďpink sistersĒ Iíve joined recently. Many of their questions concern genetic testing. (more…)

Dueling BRCA Databases: What About the Patient?

April 23, 2017

Tags: BRCA, breast cancer

The news release Monday morning grabbed my attention:

ďStudy finds wide gap in quality ofBRCA1/2variant classification between Myriad Genetics and a common public database.Ē

Myriad Genetics had been exclusively providing the tests, for $3000+ a pop for full BRCA gene sequencing, for 17 years before the Supreme Court invalidated key gene patents back in 2013. Since the ruling a dozen or so competitors have been offering the tests for much lower prices. Meanwhile, Myriad has amassed a far deeper database than anyone else, having been in the business so much longer. And itís proprietary. (more…)

Genetic Testing For All: Is It Eugenics?

September 21, 2014

Tags: genetic testing, eugenics, NIPT, BRCA, carrier testing, DNA

(NHGRI)
In recent weeks, thereís been talk of three types of genetic testing transitioning from targeted populations to the general public: carrier screens for recessive diseases, tests for BRCA cancers, and non-invasive prenatal testing (NIPT) to spot extra chromosomes in fetuses from DNA in the maternal bloodstream.

Are these efforts the leading edge of a new eugenics movement? It might appear that way, but I think not.

When I began providing genetic counseling 30 years ago at CareNet, a large ob/gyn practice in Schenectady, NY, (more…)

instruction
Project to engage students in helping families with rare genetic diseases
Book Club Reader's Guide
Many challenging questions to stimulate thought and discussion.
Instructor's Guide
38 discussion questions to get students thinking and talking about gene therapy, including the science, ethical issues, and the drug approval process.
Narrative science
The Forever Fix is the uplifting true story of 8-year-old Corey Haas, who was cured of hereditary blindness just 4 days after gene therapy.
College Textbooks
A spectacularly-illustrated, clearly written human anatomy and physiology textbook, used in pre-health profession programs throughout the U.S.
A highly engaging, clearly written, beautifully illustrated introduction to the science of human genetics for the non-scientist. Now in its 11th edition, 12th to be published in September 2018.
Nonfiction
An ideal starting point for anyone who wants to know more about genes, DNA, genomes, and the genetic ties that bind us all.

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