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Glenn Nichols, surrounded by his hospice team. The author is in yellow.

Genetic Linkage

A 31-Gene Test to Predict Alzheimerís

October 16, 2017

Tags: Alzheimer's disease, APOE4

When the direct-to-consumer genetic testing company 23andMe received FDA approval back in April to market a test for the e4 variant of the gene APOE, which is associated with elevated risk of developing late-onset Alzheimerís disease, it gave people a possible peek into their futures.

About 15 percent of the population has one or two copies of the high-risk gene variant. For a long time the risk of developing Alzheimerís for e4 double-dose individuals was 12 to 15 fold, but only 3 fold for those with one copy. Those figures have declined with re-analysis of the data.

A new 31-gene test can identify individuals at higher risk for the disease, including many who test okay for APOE e4. (Which stands for "apolipoprotein E epsilon 4 allele.")

A MORE POWERFUL TEST (more…)

instruction
Project to engage students in helping families with rare genetic diseases
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Many challenging questions to stimulate thought and discussion.
Instructor's Guide
38 discussion questions to get students thinking and talking about gene therapy, including the science, ethical issues, and the drug approval process.
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An ideal starting point for anyone who wants to know more about genes, DNA, genomes, and the genetic ties that bind us all.

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