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Glenn Nichols, surrounded by his hospice team. The author is in yellow.

Genetic Linkage

Medical Success Stories: From Cystic Fibrosis to Diabetes

September 4, 2014

Tags: cystic fibrosis, type 2 diabetes, gastric bypass, Leber congenital amaurosis, gene therapy, A1C, natural history study, adenosine deaminase deficiency, SCID-X1

The many guises of CF.
A skinny little boy, with mocha skin and curly black hair, lived in the apartment building next door when I was growing up in Brooklyn in the 1960s. He didn’t live long enough to go to kindergarten. He had cystic fibrosis.

Today’s tots with CF face a far brighter future. A recent report in the Annals of Internal Medicine applied trends in survival from 2000 to 2010 to project life expectancy for children diagnosed in 2010: 37 years for girls and 40 years for boys. (The difference may reflect hormones or the extra creatinine in the more muscular male of the species.) Factoring in the current rate of treatment improvements gives a soaring median survival of 54 years for women and 58 years for men when those kids grow up! (more…)

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Many challenging questions to stimulate thought and discussion.
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38 discussion questions to get students thinking and talking about gene therapy, including the science, ethical issues, and the drug approval process.
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An ideal starting point for anyone who wants to know more about genes, DNA, genomes, and the genetic ties that bind us all.

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