12th edition of my human genetics textbook


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Glenn Nichols, surrounded by his hospice team. The author is in yellow.

Genetic Linkage

Drug Duo Treats ALS – On A Chip

October 23, 2018

Tags: ALS

When a disease is as relentless as amyotrophic lateral sclerosis (ALS; aka Lou Gehrig’s disease; aka motor neuron disease), any promising research result is welcome news.
A study just published in Science Advances shows that two drugs already FDA-approved for other diseases, when teamed, halt neuron death and bolster muscle contraction in an “organ-on-a-chip” model of ALS. When the drugs meet in a device that places tiny balls of motor neurons from a patient next to strips of healthy skeletal muscle, the set-up not only recapitulates the disease, but shows the synergy of the drugs. They are rapamycin (Sirolimus) and bosutinib (Bosulif).

To continue reading go to DNA Science, my blog at Public Library of Science, where this post first appeared.

instruction
Project to engage students in helping families with rare genetic diseases
Book Club Reader's Guide
Many challenging questions to stimulate thought and discussion.
Instructor's Guide
38 discussion questions to get students thinking and talking about gene therapy, including the science, ethical issues, and the drug approval process.
Narrative science
The Forever Fix is the uplifting true story of 8-year-old Corey Haas, who was cured of hereditary blindness just 4 days after gene therapy.
College Textbooks
A spectacularly-illustrated, clearly written human anatomy and physiology textbook, used in pre-health profession programs throughout the U.S.
A highly engaging, clearly written, beautifully illustrated introduction to the science of human genetics for the non-scientist. Now in its 11th edition, 12th to be published in September 2018.
Nonfiction
An ideal starting point for anyone who wants to know more about genes, DNA, genomes, and the genetic ties that bind us all.

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